Berlin 2012 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 2: Nanoparticles and Composite Materials
CPP 2.11: Vortrag
Montag, 26. März 2012, 12:30–12:45, C 243
Synthesis und characterization of selective sensor nanoparticles for magnetic resonance imaging — •Daniel Nordmeyer1, Patrick Stumpf1, Dominic Gröger2, Florian Paulus2, Rainer Haag2, Annetta Semisch3, Constanze Richter3, Andrea Hartwig3, Jens Dernedde4, Ronny Malz5, Ursula Rauch-Kröhnert5, Jörg Schnorr6, Ines Gemeinhardt6, Matthias Taupitz6, Christina Graf1, and Eckart Rühl1 — 1Physikalische Chemie, FU Berlin — 2Organische Chemie, FU Berlin — 3Institut für Angewandte Biowissenschaften, Karlsruhe Institut für Technologie — 4Institut für Laboratoriumsmedizin, Klinische Chemie und Pathobiochemie, Charité — 5Centrum für Herz-, Kreislauf- und Gefäßmedizin, Charité — 6Institut für Radiologie, Charité
The aim of the present study is the synthesis of iron oxide nanoparticles (FeOx-NP) functionalized by hyperbranched sulfated polyglycerols (hPGS, a heparin analogue) on their surfaces. This leads to antiinflammatory and antimetastatic effects in organism. Stability measurements with hPGS coordinated FeOx-NP are performed in different biological media. Human colon cancer cells are incubated with these hydrophilic nanoparticles, indicating that the viability of the cells is increased. Surface plasmon resonance (SPR) studies indicate that the hPGS coordinated FeOx-NP lead to an inhibition of L-selectin binding. Finally, the binding of hPGS functionalized FeOx-NP to myocarditis infected tissue is tested, using a mice-model. These results indicate that hPGS coordinated FeOx-NP may be suitable for being used as a contrast agent in magnetic resonance imaging.