Berlin 2012 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 21: Poster: Wetting, Micro and nanofluidics
CPP 21.4: Poster
Mittwoch, 28. März 2012, 11:00–13:00, Poster A
Microparticle Separation in Droplet Based Microfluidics — •Michael Hein1, Jean-Baptiste Fleury1, and Ralf Seemann1,2 — 1Experimental Physics, Saarland University, D-66041 Saarbrücken — 2MPI for Dynamics and Self-Organization, D-37073 Göttingen
To compartment extremely small liquid volumes into droplets and manipulate them in droplet based microfluidic systems offers the benefit of inhibiting dispersion and cross contamination of analytes. For many applications like cytometry, hemotology or immunoassays molecules are attached to microbeads and subsequently dispersed in various liquids to achieve and probe certain reactions. To include those type of reactions into microfluidics devices we explore particle separation in droplets flowing in straight microfluidic channels. Particle separation might occur inside a droplet and leads to a concentration of dispersed particles at either the front or the rear end of a droplet after a short travel distance. We explore the particle separation for several parameters like density difference of the particles and the dispersed phase, particle size, viscosities of the liquids, droplet size, channel geometry, and flow velocity. After concentrating the particles, the droplet can be split into fractions containing excess dispersed phase and a large concentration of particles, which then can be used for further microfluidic processing or analyses.