Berlin 2012 – wissenschaftliches Programm

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DY: Fachverband Dynamik und Statistische Physik

DY 12: Joint focus session (with BP): Statistics of Cellular Motion

DY 12.2: Topical Talk

Dienstag, 27. März 2012, 10:00–10:30, H 1028

The statistics of eukaryotic chemotaxis — •Eberhard Bodenschatz — MPI Dynamics and Self-Organization, Goettingen, Germany

The directed motion of eukaryotic cells in a chemoattractant gradient depends on the the steepness of the gradient as well as the average concentration surrounding the cell. It was recently theoretically predicted that for a given situation the chemotactic efficacy is determined by the stochastic fluctuations of a two step process: first the binding of the signaling molecule to the transmembrane receptor and second the intracellular unbinding of a second messenger. It was suggested that the signal to noise ratio of this two stage process is sufficient to explain the chemotactic behavior. In this talk we will first introduce eukaryotic chemotaxis and the experimental micro-fluidic system for controlled chemical signals. Then we shall present the data on the random directed motion of cells and will describe it with a 2D Langevin equation. Then we show that the stochasticity of the two step process can indeed describe the experimentally observed behavior.

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