Berlin 2012 – wissenschaftliches Programm

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DY: Fachverband Dynamik und Statistische Physik

DY 22: Posters I

DY 22.13: Poster

Mittwoch, 28. März 2012, 17:00–19:00, Poster A

Introducing Ca-dependent plasticity into cortical up/down-state models — •Michael Schellenberger and Jens Christian Claussen — Institut für Neuro- und Bioinformatik, Universität zu Lübeck

Multiple studies have shown that sleep and especially the so called slow wave sleep is essential for the development of memories. However the exact mechanisms remain unknown. Therefore we investigate a biophysical model proposed by Compte et al. [1] which shows those characteristic oscillations of the membrane voltage. We introduce long term plasticity due to a Ca-dependent plasticity rule, which is based both on the trafficking and the phosphorylation/dephosphorylation of AMPA-receptors in the postsynaptic spine. In different simulations we compare several aspects of the original and the modified model and investigate the dynamical properties of the neurons with respect to the generation of long term potentiation.

[1] A. Compte et al., J. Neurophysiol 89, 2707 (2003)

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