Berlin 2012 – wissenschaftliches Programm

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DY: Fachverband Dynamik und Statistische Physik

DY 22: Posters I

DY 22.14: Poster

Mittwoch, 28. März 2012, 17:00–19:00, Poster A

Multiscale entropy of heart rate fluctuations in patients with acromegaly — •Mirjana M Platiša1, Svetozar Damjanović2, and Vera Gal11Institute of Biophysics, School of Medicine, Belgrade University, Belgrade, Serbia — 2Institute of Endocrinology, Clinical Center Serbia, Belgrade, Serbia

Recent evidence suggests that the loss of complexity in time-series may be a generic feature of pathologic dynamics. Hence, we have studied complexity of the time-series of heart interbeat (RR) intervals in patients with acromegaly using multiscale entropy (MSE). ECG was recorded during sleeping period in 10 patients with acromegaly (AP), and 7 age matched (AM) healthy subjects and 7 young healthy subjects. The whole data time-series of RR intervals were analyzed. The MSE curve profiles were different for these three groups. Complexity measure obtained over scale one is the highest in young healthy subjects and there is no difference between AP and AM subjects. However, at higher scales complexity is the highest in AP, and slightly higher in young subject than in AM group. These results reveal that long range heart rhythm complexity is significantly influenced by the excess of growth hormone.

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