Berlin 2012 – wissenschaftliches Programm
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MA: Fachverband Magnetismus
MA 20: Poster I - Biomagnetism, FePt Nanoparticles, Magnetic Particles/Clusters, Magnetic Materials, Magnetic Semiconductors, Half-metals/Oxides, Multiferroics, Topological Insulators, Spin structures/Phase transitions, Electron theory/Computational micromagnetics, Magnetic coupling phenomena/Exchange bias, Spin-dependent transport, Spin injection/spin currents, Magnetization/Demagnetization dynamics, Magnetic measurement techniques
MA 20.9: Poster
Dienstag, 27. März 2012, 12:15–15:15, Poster A
Characterization of superparamagnetic nanoparticles for bone tissue engineering — •M. Uhlarz1, T. Herrmannsdörfer1, R. De Santis2, M. Sandri3, A. Tampieri3, E. Figallo4, T. D’Alessandro4, S. Keshari-Samal5, G. Rischitor6, and the MAGISTER collaboration7 — 1Hochfeld-Magnetlabor Dresden, HZ Dresden-Rossendorf — 2IMCB-CNR, Napoli, Italia — 3ISTEC-CNR, Faenza, Italia — 4Fin-Ceramica SpA, Faenza, Italia — 5ISMN-CNR, Bologna, Italia — 6Western General Hospital, University of Edinburgh, UK — 7Europäische Kommission, Bruxelles, Belgique
Currently, large bone or cartilage defects are stabilized by massively-invasive surgery. The permanent implants used for this purpose are either metallic prostheses, or body tissue taken elsewhere from the patient. In a novel tissue-engineering approach, autologous tissue regeneration is guided by implanted magnetic scaffolds under external magnetic field. These scaffolds attract superparamagnetic Fe3O4 (magnetite) nanoparticles tagged with Vascular Endothelial Growth Factor (VEGF) molecules. Release of the growth-factor molecules at the scaffold (optionally triggered by ac-field induced hyperthermia) attracts autologous chondrocytes and osteoblasts, which build up fresh bone and cartilage tissue. We report on the magnetic characterization of several biocompatible and biodegradable materials that might serve as scaffold materials.
This project is supported by the European Union’s FP7-Cooperation Programme through the MAGISTER project (Magnetic Scaffolds for in-vivo Tissue Engineering), Large Collaborative Project FP7 - 21468.