Berlin 2012 – wissenschaftliches Programm

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PV: Plenarvorträge

PV 19: PV XIX

PV 19.1: Preisträgervortrag

Donnerstag, 29. März 2012, 13:15–14:00, H 0105

Mechanics and Growth of Tissues — •Jean-Francois Joanny — Institut Curie centre de recherche 26 rue d'Ulm 75248 Paris cedex 05 — Laureate of the Gentner-Kastler-Prize

We present a mechanical model to describe the growth of healthy and cancerous tissues.

We first show that because of the coupling between cell division and the local stress, a tissue can be considered as a visco-elastic liquid with a relaxation time smaller than the cell division time. We propose a two fluid-model taking into account the interstitial fluid between the cells. We then discuss various instabilities of epithelial tissues that can be of physiological relevance : -villis are the protrusions of the surface of the intestine or the colon. We describe the formation of villis as a buckling instability of a polar cell monolayer. The polarity of the layer does not seem to play a role in the intestine where the villis are arranged in a square array but it is important in the colon where they are organized in a hexagonal array. -tubular tissue structures such as arteries or the renal excretory canals show various instabilities also related to buckling -thick epithelia have a fingering instability of their basement membrane