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Berlin 2012 – wissenschaftliches Programm

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PV: Plenarvorträge

PV 22: PC XXII

PV 22.1: Preisträgervortrag

Donnerstag, 29. März 2012, 14:00–14:45, EW 201

3D imaging of lung tissue during total liquid ventilation — •Christian Schnabel1,2, Sven Meissner1, Maria Gaertner1, and Edmund Koch11Faculty of Medicine Carl Gustav Carus, University of Technology, Dresden, Germany — 2Laureate of the Georg-Simon-Ohm-Prize

Abstract: The knowledge of lung mechanics on an alveolar level is crucial for the investigation and development of new and more protective artificial ventilation methods. To acquire data describing the lung behavior of alveolar structures, a high-resolution imaging modality is necessary. A suitable, non-invasive, contactless and three-dimensional imaging modality to visualize subpleural alveoli in animal models with a high microscale resolution is optical coherence tomography (OCT). The main limitation of OCT is the scattering loss of the backscattered near-infrared light in higher depth due to the refractive index changes at each air-tissue interface. For in vivo measurements the refractive index inside the alveoli can be matched to the one of the surrounding tissue by using suitable breathing liquids and a custom-made liquid ventilator. We use this approach to improve information content of 3D OCT images to investigate lung behavior during different conditions of artificial ventilation. The setup of the developed ventilator and first results showing the feasibility of liquid ventilation to improve OCT imaging of alveolar structures and enhance the information content obtained from those data will be presented.

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