Berlin 2012 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 4: Poster
ST 4.10: Poster
Dienstag, 27. März 2012, 10:10–11:30, Poster F
Ensemble of cell survival experiments after ion irradiation for validation of RBE models — •Thomas Friedrich1, Uwe Scholz1, Marco Durante1,2, and Michael Scholz1 — 1GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt — 2Institut für Festkörperphysik, TU Darmstadt, 64289 Darmstadt
There is persistent interest in understanding the systematics of the relative biological effectiveness (RBE). Models such as the Local Effect Model (LEM) or the Microdosimetric Kinetic Model have the goal to predict the RBE. For the validation of these models a collection of many in-vitro cell survival experiments is most appropriate.
The set-up of an ensemble of in-vitro cell survival data comprising about 850 survival experiments after both ion and photon irradiation is reported. The survival curves have been taken out from publications. The experiments encompass survival curves obtained in different labs, using different ion species from protons to uranium, varying irradiation modalities (shaped or monoenergetic beam), various energies and linear energy transfers, and a whole variety of cell types (human or rodent; normal, mutagenic or tumor; radioresistant or -sensitive). Each cell survival curve has been parameterized by the linear-quadratic model. The photon parameters have been added to the data base to allow to calculate the experimental RBE to any survival level.
We report on experimental trends found within the data ensemble. The data will serve as a testing ground for RBE models such as the LEM. Finally, a roadmap for further validation and first model results using the data base in combination with the LEM are presented.