Berlin 2012 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 5: Advanced Radiation Therapy
ST 5.5: Vortrag
Mittwoch, 28. März 2012, 11:10–11:30, HFT-FT 101
Predicting the effect of charged particles for instantaneous and protracted irradiation — Lisa Herr1, Francesco Tommasino1, Adrian Seeger1, Uwe Scholz1, •Thomas Friedrich1, Marco Durante1,2, and Michael Scholz1 — 1GSI Helmholtzzentrum für Schwerionenforschung, 64291 Darmstadt — 2Institut für Festkörperphysik, TU Darmstadt, 64289 Darmstadt
The local effect model (LEM) predicts the relative biological effectiveness for charged particle radiation based on the dose response of radiation with low linear energy transfer such as X-rays. The induction of DNA double strand breaks after irradiation is simulated according to the track structure of charged particles. The effect of these lesions is then derived from the effect after photon irradiation causing a similar damage pattern. The LEM has been tested thoroughly using in-vitro and in-vivo experiments as well as clinical findings of carbon ion therapy.
General properties of dose response curves can be derived from the conceptual basis of the LEM. Furthermore, insight in damage repair kinetics and the response to time dependent dose delivery is gained.
In this contribution, the concept of the LEM is reviewed and some examples for its applicability are briefly discussed. General properties of the dose response curves are motivated. Finally, cell survival curves after protracted irradiation as well as the measured time dependence of residual damage after instantaneous irradiation are compared with the model predictions. Here, good agreement is found.