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Regensburg 2013 – scientific programme

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BP: Fachverband Biologische Physik

BP 25: Posters: Cytoskeleton

BP 25.5: Poster

Wednesday, March 13, 2013, 17:30–19:30, Poster C

Dynamics and length distribution of microtubules under force and confinementBjörn Zelinski, •Nina Müller, and Jan Kierfeld — Physics Department, TU Dortmund, Dortmund, Germany

We investigate the microtubule polymerization dynamics with catastrophe and rescue events for three different confinement scenarios: (i) The microtubule is confined by rigid and fixed walls, (ii) it grows under constant force, and (iii) it grows against a linearly increasing force. (i) In confinement, we find exponentially decreasing or increasing stationary microtubule length distributions instead of bounded or unbounded phases and introduce a model for wall-induced catastrophes. (ii) Under a constant force the boundary between bounded and unbounded growth is shifted to higher tubulin concentrations and rescue rates. We determine the critical force fc which provides the transition from unbounded to bounded growth. (iii) For growth against an elastic obstacle and a non-zero rescue rate, we find a sharply peaked steady state length distribution. The corresponding average length self-organizes such that the average polymerization force equals the critical force fc for the transition from unbounded to bounded growth.

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