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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 2: Interfaces and Thin Films I (joint session with DECHEMA and VDI)

CPP 2.4: Talk

Monday, March 11, 2013, 10:30–10:45, H40

Nanoparticle-induced permeability of lipid bilayer membranes — Sergey Pogodin¹, •Marco Werner^2,3, Jens-Uwe Sommer^2,3, and Vladimir A. Baulin^4,5 — ¹Institut Català d’Investigació Química, Tarragona, Spain — ²Leibniz-Institut für Polymerforschung Dresden, Germany — ³Technische Universität Dresden, Germany — ⁴Universitat Rovira i Virgili, Tarragona, Spain — ⁵ICREA, Barcelona, Spain

Using lattice Monte Carlo simulations with explicit solvent we investigate interactions of nanoparticles with self-assembled bilayer membranes as function of nanoparticle hydrophobicity and heterogeneity of amphiphilic site distribution. Our simulation results indicate, that there is an adsorption transition for nanoparticles at the model membrane for intermediate values of nanoparticle hydrophobicity, where the effective repulsions from solvent- and lipid tail environments are balanced. Close to this transition, we observe a significant frequency increase of nanoparticle translocations through the bilayer as well as an increased bilayer permeability for solvent. Depending on nanoparticle concentration we observe clustering of homogeneous nanoparticles to larger agglomerates perturbing the membrane on a larger scale. Amphiphilic nanoparticles as used in our study do not agglomerate and show an enhanced localization at the bilayer surface as compared to homogeneous nanoparticles.