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BP: Fachverband Biologische Physik

BP 26: Multi-cellular systems and Physics of Cancer

BP 26.1: Talk

Wednesday, April 2, 2014, 11:45–12:00, ZEU 250

Modeling the electrical excitation in a cross section of the human heart with simultaneous consideration of varied cell-type distribution, fiber-angle rotation and stimulation protocol. — •Maximilian Eisbach¹, Stefan Fruhner², Harald Engel¹, and Markus Bär² — ¹TU Berlin — ²PTB Berlin

The anisotropy of the electrical conduction system in a human heart is believed to play a critical role in the electrical wavefront dynamics. Yet, the validity of rule based approaches for embedding fibre orientation and cell-type distribution remains unclear. We investigated the influence of different fibre assignments and cell type distribution on the propagation of the electrical excitation in a 2D slice obtained from MRI measurements of a human heart. Since a cross section is a radical simplification of the 3D structure of the human heart, we additionally studied the impact of varying stimulation protocols. We conclude that the stimulation position has a greater influence on the shape of the excitation wave in a cross section of the heart, than differing anisotropy of the electrical conduction system.