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BP: Fachverband Biologische Physik
BP 26: Multi-cellular systems and Physics of Cancer
BP 26.6: Vortrag
Mittwoch, 2. April 2014, 13:00–13:15, ZEU 250
Multiple mutations in hierarchically organized tissues. — •Benjamin Werner1, David Dingli2, and Arne Traulsen1 — 1Max Planck Institute for Evolutionary Biology, Plön Germany — 2Mayo Clinic, Rochester USA
Cancers are rarely caused by single mutations, but often develop based on the combined effects of multiple mutations. For most cells, the number of possible cell divisions is limited due to various biological constrains, as for example progressive telomere shortening or a hierarchically organized tissue structure. Thus, the risk of accumulating cells carrying multiple mutations is low. Nonetheless, many diseases are based on the accumulation of such multiple mutations. We model a general, hierarchically organized tissue by a multi compartment approach, allowing any number of mutations within a cell. I present closed solutions for the deterministic clonal dynamics and the reproductive capacity of single clones. I show that hierarchically organized tissues strongly suppress cells carrying multiple mutations and derive closed solutions for the expected size and diversity of clonal populations founded by a single mutant within the hierarchy.
References:
Werner B., Dingli D., Lenaerts T., Pacheco J. M., and Traulsen A. Dynamics of mutant cells in hierarchical organized tissues. PLoS Computational Biology 2011(e1002290)
Werner B., Dingli D. and Traulsen A. A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues. Journal of the Royal Society Interface 2013 (10)