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BP: Fachverband Biologische Physik

BP 41: Biomaterials and Biopolymers II (joint CPP/BP)

BP 41.4: Talk

Thursday, April 3, 2014, 15:45–16:00, ZEU 222

Multivalent Ligand Design — •Susanne Liese and Roland Netz — FU Berlin, Berlin

The binding strength of multivalent ligands of different geometry and rigidity is studied, using an analytic statistical mechanics model. By varying the spacer length between the ligand units, the binding strength is optimized. It is found that for low association constants of the monovalent ligand, even an optimized multivalent structure, does not bind better than the monovalent correspondent. The critical association constant above which a multivalent ligand enhances binding, depends cubically on the distance between the receptor binding sites. In all systems we find that a multivalent ligand binds best, if the average spacer length is in the range of the receptor binding site distance and if the spacer is as stiff as possible.