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BP: Fachverband Biologische Physik

BP 42: Biotechnology and bioengineering

BP 42.4: Talk

Friday, April 4, 2014, 10:15–10:30, HÜL 386

Two-photon composition and modification of a PEG-based hydrogel — •Christiane Jungnickel¹, Mikhail Tsurkan², Carsten Werner², and Michael Schlierf¹ — ¹B CUBE - Center for Molecular Bioengineering, Dresden, Germany — ²IPF - Leibniz-Institut für Polymerforschung Dresden e.V, Dresden, Germany

Hydrogels are used on an everyday basis in a lot of different fields like contact lenses [1], biomimetic scaffolding [2] and drug delivery [3]. Hydrogels are becoming increasingly popular in biological and medical sciences because of their broad application possibilities for tissue engineering.

Here, we present a novel approach to build up a hydrogel with nanometer precision in 3D around a living cell via two-photon reaction [4]. In comparison to previous approaches, the polymer based hydrogel does not require photoinitiators for its reaction. The two-photon process allows a high spatial and temporal control and enables furthmore a precise surface or volume structuring with a broad selection of functionalized biomolecules. Therefore it is now possible to trap cells in a hydrogel cage, manipulate and release them afterwards.

[1] O. Wichterle et al., Nature 185, 117 (1960)

[2] P.B. Welzel et al., Polymers 3, 602 (2011)

[3] T. Nermonden et al., Chem. Rev. 112, 2853 (2012)

[4] M.Pawlicki et al., Angew. Chem. Int. Ed. 48, 3244 (2009)