Dresden 2014 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 6: Posters: Membranes and vesicles

BP 6.1: Poster

Montag, 31. März 2014, 17:30–19:30, P3

Modeling vesicular transport in Chromaffin cells — •Daungruthai Jarukanont — university of Kassel, Kassel, Germany

In cell communications, the transport of vesicles is essential for storage and release of chemical messenger molecules. Here, we demonstrate that the statistical analysis of electrophysiological measurements viewed as a time series of spikes permits to determine the equation of motion governing vesicle transport. We perform amperometric measurements of Chromaffin cells for inter-release events interval analysis. Histogram of most recording follow Inverse-Gaussian distribution which can be connected to Brownian motion of particles with a drift term. Therefore we model the vesicles as diffusive particles with external force in membrane direction. Their motion follow over-damped Langevin equation with constant drift velocity, and their density evolve by the corresponding Fokker-Planck equation. The simulations are able to reproduce our and others published experiments in good agreement.