Dresden 2014 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 35: Biomaterials and Biopolymers (joint session with BP) I
CPP 35.7: Vortrag
Mittwoch, 2. April 2014, 17:00–17:15, ZEU 222
Biomodified, stimuli responsive surface coatings based on polymer brushes — •Evmorfia Psarra1, 2, Ulla König1, Klaus-Jochen Eichhorn1, Manfred Stamm1, 2, and Petra Uhlmann1 — 1Leibniz-Institut für Polymerforschung Dresden e.V., Dresden, Germany — 2Technische Universität Dresden, Physical Chemistry of Polymer Materials, Dresden, Germany
The main focus of this work is the surface biofunctionalization of ultra-thin, stimuli responsive polymer brushes grafted to model surfaces. Different polymer brushes either composed out of a pH responsive component, the Poly(acrylic) acid (PAA), and/or a temperature responsive material, the Poly(N-isopropyl acrylamide) (PNIPAAm) are used to investigate the Arg-Gly-Asp (RGD) peptide binding to the brush surface. Using PNIPAAm mixed with PAA polymer material in order to generate binary brushes will help to create smart surface coatings which are hiding or exposing their functionalities by changing the temperature from physiological (37°C) to room temperature. Binary brushes functionalized with cell-signaling molecules, can lead to intelligent stimuli-responsive bio-nanosurfaces, able to regulate cell adhesion and function. Here we are presenting detailed surface analysis results for the PNIPAA-PAA RGD modified system.