Dresden 2014 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 54: Poster Session 3
CPP 54.52: Poster
Donnerstag, 3. April 2014, 15:00–19:00, P2
Star-PEG-Heparin-Polyelectrolyte-Hydrogels - Rate Theory and Reaction Kinetics — •Ron Dockhorn1,2 and Jens-Uwe Sommer1,2 — 1Leibniz-Institut für Polymerforschung Dresden e.V., D-01069 Dresden, Germany — 2Technische Universität Dresden, Institut für Theoretische Physik, D-01069 Dresden, Germany
We are studying biohybrid hydrogels made of heparin, a rod-like highly charged glycosaminoglycan as a highly functionalized cross-linker, and non-charged, elastic 4-arm star-shaped-polyethylene glycol by using theory and simulations. We focus on the network structure and reaction kinetics by using the bond-fluctuation simulation method and determine the higher order defects at different initial conditions comparing to the rate theory. Also, we investigate the influence of the initial molar ratio, the variations of functionalized groups, and the concentration dependence of the reaction mixture on the reaction kinetics of the defects and on the percolation threshold of the gels. These findings are useful to optimize the mechanical properties of this biohybrid hydrogels for cell replacement-based therapies.