Dresden 2014 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 54: Poster Session 3

CPP 54.63: Poster

Donnerstag, 3. April 2014, 15:00–19:00, P2

In Situ particle degradation of hyperbranched polyglycerol particles via Atomic Force Microscopy — •Marcel Richter and Regine von Klitzing — TU Berlin, Straße des 17. Juni 124, 10623 Berlin

During the last decades hyperbranched polymers made of polyethylene glycerol (PEG) have attracted much interest in applications like drug delivery and sensors [1]. Due to their biocompability and multifunctionallity these particles afford the formation of efficient drug carriers [2]. The drug loading with these particles can be realised by the encapsulation during the particle synthesis. This guarantees a homogenous drug distribution with in the carrier. The drug release can be triggered by the particle degradation in response to biological stimuli such as changes in pH [3]. The particle degradation has been followed by atomic force microscopy (AFM) as a function of time. It has been found that particle erosion occurs with an exponential decay within the first minutes. Further progress in the degradation process leads to a slow down of the particle erosion. On the other hand, the particle degradation in bulk shows linear particle erosion. [1] *R. Haag, F. Kratz, Angew. Chem. Int. Ed. (2006), 45, 1198 [2] K. Knop et al., Chem. Int. Ed., (2010), 49, 6288 [3]*E. Fleige et al., Adv. Drug Deliv. Rev. (2012), 64, 866