Dresden 2014 – wissenschaftliches Programm
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O: Fachverband Oberflächenphysik
O 36: Posters: Bio/organic Molecules on Surfaces, Graphene, Solid/liquid interfaces, Metal Substrates, Electronic Structure Theory
O 36.17: Poster
Dienstag, 1. April 2014, 18:30–22:00, P1
Understanding the peptide folding on surfaces in UHV by electrospray ion beam deposition (ES-IBD) — •Sabine Abb1, Gordon Rinke1, Stephan Rauschenbach1, Ludger Harnau2,3, and Klaus Kern1,4 — 1Max-Planck-Institute for Solid State Reserach, Heisenbergstr. 1, Stuttgart — 2Max-Planck-Institute for Intelligent Systems, Heisenbergstr. 3, Stuttgart — 3IV. Institute for Theoretical Physics, University Stuttgart, Pfaffenwaldring 57, Stuttgart — 4Ecole Polytéchnique Fédérale de Lausanne, Switzerland
Specific functionality of peptides and proteins is reached by folding into a unique secondary and tertiary structure which is steered by intramolecular interactions as well as metal coordination. A new route to investigate the properties and structural formation of amino acid sequences on surfaces in low dielectric environments ( e.g. in vacuo) is possible with our home-built ES-IBD instrument which allows in-situ STM characterization of (bio)molecules. It also gives additional modes of control, for instance by using selected charge states and generating metal-peptide complexes which already form in solution.
Here we show preliminary results of STM investigations of the eight-amino acid peptide angiotensin II on various metal surfaces. We observe dimer to multimer self-assembled structures and present preliminary structural models. For a deeper understanding of the ongoing processes, special attention is paid to the structural differences and similarities between the protonated and coordinated angiotensin II as well as the comparison to the nine-amino acid peptide Bradykinin.