Berlin 2015 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 15: Posters: Multi-cellular systems
BP 15.9: Poster
Montag, 16. März 2015, 17:30–19:30, Poster A
A computational model of tumor growth based on large scale vascular networks — Michael Welter1, •Thierry Fredrich1, Heiko Rieger1, and Herbert Rinneberg2 — 1Saarland University — 2PTB Berlin
The process of tumor growth is very complex. Even today it is hard to predict the outcome of the disease and the effect of various therapies. Theoretical simulations can help to make such predictions and allow tailoring the therapy to patient specific microenvironments such as the blood vessel network.
On the way there, we consider the creation of a healthy host vessel system by stochastic growth of a hierarchical arteriovenous network (described in [1]) as starting point. Parameters can be adjusted to yield networks with global properties like MVD, vascular volume and perfusion, which agree very well with data from real tissue. We treat the bulk of tumor cells with a continuum approach following [2] and consider vessels as linelike sources or sinks for nutrients, coupled to the tissue layer via some transvascular flux.
Interstitial fluid flow, for example, is a key element of chemotherapy, however not yet fully understood. The locally available nutrients play another important role in cancer proliferation. We investigate those aspects using a model [3] inspired by morphological data from human melanoma and breast tumors. We were able to quantitatively reproduce IR mammography data [4] showing the oxygen content of breast carcinomas in vivo.
[1] Gödde and Kurz, [2] Preziosi, [3] Welter and Rieger, [4] Rinneberg