Berlin 2015 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 22: Posters: Cytoskeletal filaments

BP 22.15: Poster

Dienstag, 17. März 2015, 14:00–16:00, Poster A

Composite networks of actin and intermediate filaments — •Tom Golde¹, Martin Glaser¹, Carsten Schuldt¹, Jörg Schnauß¹, Harald Herrmann², and Josef Käs¹ — ¹University of Leipzig, Faculty of Physics, Soft Matter Physics Division, Leipzig, Germany — ²German Cancer Research Center, Division of Molecular Genetics, Heidelberg, Germany

Cell deformability is mainly determined by cytoskeletal filaments like actin and intermediate filaments. Rheological network properties are quite well understood for networks composed of a single filament type. Actin networks are described by common models for semiflexible polymer networks. In contrast, some intermediate filaments like keratin show a high elastic modulus at low protein concentration that cannot be explained with these simple models. Cells contain not only one but several types of filament networks. Their rheological behavior cannot simply be deduced from single type network properties.

We want to address this problem with a two-step in vitro approach. First, we will study actin, keratin, and vimentin networks with shear and microrheology under comparable boundary conditions. The next step in understanding cell deformability is the investigation of composite networks made of these previously examined filament types.