Berlin 2015 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 27: Posters: Complex Fluids and Soft Matter

BP 27.2: Poster

Dienstag, 17. März 2015, 14:00–16:00, Poster A

Nonlinear Dynamics Model Of Epithelial Tissue — •Wei-Lung Lo and Hsuan-Yi Chen — Department of Physics, Nation Central University, Jhongli, 32001, Taiwan.

In spite of recent experimental and theoretical advances in the study of the homeostasis of biological tissues, not much is known about the relaxation dynamics of a tissue toward its homeostasis state. In this work we propose a theoretical model to study this problem. The tissue is composed of stem cells and terminal differentiated cells (TDs). The stem cells divide at a rate r*s and TD cells undergo apoptosis at a rate rd. The self-renewal probability of a stem cell after cell division is assumed to be P*(N*_D) , a function of the total number of TD cells. Our model shows that a biological tissue could allow the existence of multiple steady states. The relation between the steady state properties of the tissue and the corresponding biomolecular processes is addressed. Furthermore, the stability of the homeostasis for a stratified epithelium is studied. We show that the relaxation rate of a tissue towards its homeostasis state is controlled by (i) viscous flow induced by tissue surface tension (ii) adjusted cell proliferation rate (iii) coupling between cell proliferation and flow field in the tissue. The question of how tissue competition affects the relaxation of tissue around a homeostasis state is addressed.