Berlin 2015 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 36: Cell adhesion, mechanics and migration II

BP 36.7: Vortrag

Mittwoch, 18. März 2015, 17:00–17:15, H 1058

Spontaneous actin dynamics in contractile rings — Viktoria Wollrab^1,2, Raghavan Thiagarajan^1,2, Daniel Riveline^1,2, and •Karsten Kruse³ — ¹Laboratory of Cell Physics, Institut de Science et d'Ingénierie Supramoléculaires, 67083 Strasbourg, France — ²Laboratory of Cell Physics, Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch, France — ³Theoretische Physik, Universität des Saarlandes, 66123 Saarbrücken, Germany

Networks of polymerizing actin filaments are known to be capable to self-organize into a variety of structures. For example spontaneous actin polymerization waves have been observed in living cells in a number of circumstances, notably, in crawling neutrophils and slime molds. During later stages of cell division, they can also spontaneously form a contractile ring that will eventually cleave the cell into two daughter cells. We present a framework for describing networks of polymerizing actin filaments, where assembly is regulated by various proteins. It can also include the effects of molecular motors. We show that the molecular processes driven by these proteins can generate various structures that have been observed in contractile rings of fission yeast and mammalian cells. We discuss a possible functional role of each of these patterns.