Berlin 2015 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 41: Protein structure and dynamics I
BP 41.6: Vortrag
Donnerstag, 19. März 2015, 11:30–11:45, H 1058
Self-assembled protein nanofibers as basis for novel biomaterials — •Christian Helbing1, Gang Wei2, Tanja Deckert-Gaudig3, and Klaus D. Jandt1 — 1Chair of Materials Science (CMS), Otto-Schott-Institute of Materials Research (OSIM), Friedrich Schiller University Jena, Jena, Germany — 2Hybrid Materials Interfaces Group, University of Bremen, Bremen, Germany — 3Institute for Photonic Technology, Jena, Germany
Protein nanofibers (PNFs) are promising materials for numerous applications in the field of biomedical engineering. Especially, self-assembled PNFs based on plasma proteins have a high importance due their easy fabrication and high biocompatibility. However, knowledge about the self-assembly mechanism and the properties of such PNFs is limited. The aim of the current study is to deepen the understanding of the formation mechanism. We tested the hypotheses that properties, morphology and inner structure of PNF depends on environmental conditions. In this work, we present first results of self-assembled PNF structures formed in solution from different plasma proteins and plasma protein combinations. The observed morphology and mechanical properties of the formed PNFs depended strongly on the formation conditions. The structural analysis suggest that a partial denaturation, i.e. a change in the secondary structure, of the plasma proteins is a necessary requirement for the formation of PNFs. The comparison of the secondary structure of the PNFs and the native proteins helps to improve the understanding of the self-assembly mechanism. The current results leads to a better control during the PNF formation.