Berlin 2015 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 46: Biomaterials and Biopolymers II (joint CPP/BP)

BP 46.1: Vortrag

Donnerstag, 19. März 2015, 15:00–15:15, C 264

Dynamic and static force measurements on (PLL/HA)n multilayer films by atomic force microscopy — •Johannes Hellwig and Regine von Klitzing — Stranksi-Laboratorium, TU Berlin, Berlin

In recent years smart biomaterials have become a highly developing field of interest for biomedical applications, e.g. drug delivery(1). The layer-by-layer (LbL) technique (2) gives the opportunity to build up self assembled polyelectrolyte multilayer films (PEM) with defined architecture, physical and chemical properties. PEM made of poly(L-lysine) (PLL) and hyaluronic acid (HA) were produced by using the LbL technique. Potential applications of these PEMs require controlling of the adhesion behaviour by tuning their elastic/viscoelastic properties.

In this study elastic(3) and viscoelastic properties of LbL coated poly(L-lysine)/hyaluronic acid PLL/HA films were studied by colloidal probe atomic force microscopy. It was shown that the indentation modulus of PLL/HA films measured in different pH, ionic strength and temperature of the surrounding medium changes. Furthermore the viscoelastic film behaviour was measured and calculated by dynamic force measurements.

(1) Volodkin, D. V.; Larionova, N. I.; Sukhorukov, G. B. Biomacromolecules 2004, 5, 1962.

(2) Decher, G. Science 1997, 277, 1232.

(3) Üzüm, C.; Hellwig, J.; Madaboosi, N.; Volodkin, D.; v. Klitzing, R. Beilstein J. Nanotechnol. 2012, 3, 778.