Berlin 2015 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 46: Biomaterials and Biopolymers II (joint CPP/BP)
BP 46.7: Vortrag
Donnerstag, 19. März 2015, 16:45–17:00, C 264
Investigation of the lateral arrangement of phospholipid monolayers with respect to the adsorption of hyaluronan* — •Florian Wieland1, Thomas Zander1, Sören Gayer1, Andra Dedinaite2, Per Claesson2, Vasyl Haramus1, and Regine Willumeit-Römer1 — 1Helmholtz Zentrum Geesthacht, Max Planck Str. 1, 21502 Geesthacht — 2KTH Royal Institute of Technology, School of Chemical Sciences and Engineering, Department of Chemistry, Surface and Corrosion Science, Drottning Kristinas väg 51, SE-10044 Stockholm, Sweden
The unmatched tribological performance of articulated joints is due to both the properties of the cartilage itself and the assumed self-organization of the molecules in the synovial fluid and at the surface of cartilage. Phospholipids form lamellar structures on cartilage surfaces and are able to reduce friction and wear. We performed x-ray reflectivity and grazing incidence diffraction measurements on Langmuir layers of Dipalmitoylphosphatidylcholine and investigated how the adsorption of hyaluronan (HA) changes the arrangement of the lipids. In the course of the experiment we changed parameters like the molecular weight (MW) and the salt concentration in the subphase, in order to determine the key parameters.
Our data indicate that the adsorption strongly depends on the MW of HA and further on the presence of divalent ions in the subphase.