Berlin 2015 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 46: Biomaterials and Biopolymers II (joint CPP/BP)
BP 46.8: Vortrag
Donnerstag, 19. März 2015, 17:00–17:15, C 264
Interaction of Hyaluron and Phospholipids at high hydrostatic pressure — •Thomas Zander1, Florian Wieland1, Min Wang2, Akanksha Raj2, Per Claesson2,3, Andra Dedinaite2,3, Vasyl Haramus1, Regine Willumeit-Römer1, and Andreas Schreyer1 — 1Helmholtz Zentrum Geesthacht, Institute for Materials Research, DE-21502 Geesthacht — 2KTH Royal Institute of Technology, School of Chemical Sciences and Engineering, SE-10044 Stockholm — 3SP Technical Research Institute of Sweden, SP Chemistry, SE-11486 Stockholm
Articular joints are bio-lubrication systems with the lowest friction coefficients found in nature. The friction coefficient is provided by the synovial fluid, which is an intricate composition of different macromolecules (e.g. phospholipids and hyaluronan) and which keep the exceptional good lubrication properties even under high loads and shear rates. It is thought that the different constituents form complex structures in order to enable this low friction coefficients.
X-ray reflectivity measurements at different hydrostatic pressures (60bar - 2kbar) on silicon supported phospholipid- and phospholipid hyaluronen composite layers have been performed in order to gain information about their structural arrangement. Parameters like, temperature, molecular weight of the hyaluronan and ions in the solvent solution have been varied, to identify possible key parameters for good lubrication. Our results clearly reveal differences in the behaviour of the phospholipid hyaluronen composites due to different solvent conditions.