Berlin 2015 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 49: Molecular motors
BP 49.5: Vortrag
Donnerstag, 19. März 2015, 18:00–18:15, H 1028
Time scales explain different transport behavior of elastically coupled molecular motors — •Florian Berger1, Corina Keller2, Stefan Klumpp2, and Reinhard Lipowsky2 — 1Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 10065 New York, USA — 2Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany
Cellular transport is achieved by the cooperative action of molecular motors which are elastically linked to a common cargo. When the motors pull on the cargo at the same time, they experience fluctuating elastic strain forces induced by the stepping of the other motors. These elastic coupling forces can influence the motors' stepping and unbinding behavior. To develop an intuitive understanding of cargo transport by two elastically coupled motors exposed to an external load force, we introduced four different time scales for four different processes: (i) spontaneous unbinding, (ii) force induced unbinding, (iii) force induced stalling and (iv) load sharing. In particular the time scale for load sharing allows us to predict how the regulation of single motor parameters influence the cooperativity.