Berlin 2015 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 5: Nanoparticles and Composite Materials I (joint CPP/BP)
BP 5.9: Vortrag
Montag, 16. März 2015, 12:00–12:15, C 243
Drug delivery to cancer cells by nanodiamonds — •Anna Ermakova1, Yuzhou Wu2, Boris Naydenov1, Tanja Weil2, and Fedor Jelezko1 — 1Institute of Quantum Optics, University Ulm, Ulm, Germany — 2Institute of Organic Chemistry III, University Ulm, Ulm, Germany
The numbers of new cancer cases increase every year, and only few last years in some country the numbers of deaths were stable or decreased [1], this is result of progress in medicine. The main problem of the cancer therapy is the precise drug delivery to cancer cells with the exception of healthy cells. The direct drug delivery can bring a lot of advantages: reduction of the total amount of uptaken drug, more stable drug level in the specific sides, potential reduction of the drug in healthy unaffected tissues, and reduction of dosages frequency. Nanodiamonds (NDs) are potentially good drug carriers since they are non-toxic [2], their surfaces can be chemically functionalized [3] and they can be easily inserted into cells [4]. Furthermore, colour defect centres in NDs can be used as photostable biomarkers compared to quantum dots and dyes. In our work to release drug we used the property of the tumour tissue to have on average a lower pH level than healthy tissue [5]. We demonstrate a drug release from NDs in the solution, triggered by change in the pH, and inside HeLa cells. We show that only drugs penetrate into a cell nucleus and NDs stay at the cytoplasm. [1]R.Siegel et al,CA Cancer J Clin,63(2013) [2]A.M.Schrand et al,J Phys Chem B,111(2007) [3]A.Datta et al.,Nanotechnology,22(2011) [4]F.Neugart et al.,NanoLett.,7(2007) [5]R.Jain,J of Controlled Release,53(1998)