Berlin 2015 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 9: Biomaterials and Biopolymers I (joint BP/CPP)
BP 9.4: Vortrag
Montag, 16. März 2015, 15:15–15:30, EB 202
Hydrodynamic Slip on DNA in Nanopore Translocation Experiments — Lukas Galla1, •Andreas J. Meyer1, Andre Spiering1, Andy Sischka1, Michael Mayer2, Adam R. Hall3, Peter Reimann1, and Dario Anselmetti1 — 1University of Bielefeld, Germany — 2University of Michigan, USA — 3Wake Forest University School of Medicine, USA
In a recent paper, we reported on the observation of hydrodynamic slip on DNA by optical tweezers-controlled translocation experiments in solid-state and lipid-coated nanopores [1]. After a short introduction to the performed experiments, I will present our theoretical model describing the dominating electrohydrodynamic effects, with particular emphasis on the hydrodynamic slip boundary condition.
By solving the Poisson-Nernst-Planck and Stokes equations using finite element methods it is possible to gain insight into the influence of nanopore geometry and composition on translocation experiments. Furthermore, these continuous models of electrohydrodynamics can serve as an appropriate basis for dynamic DNA simulations.
[1] L. Galla, A. J. Meyer, A. Spiering, A. Sischka, M. Mayer, A. R. Hall, P. Reimann, and D. Anselmetti (2014). Hydrodynamic slip on DNA observed by optical tweezers-controlled translocation experiments with solid-state and lipid-coated nanopores. Nano Letters, 14(7), 4176-4182.