Berlin 2015 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 28: New Instruments and Methods
CPP 28.4: Vortrag
Dienstag, 17. März 2015, 14:45–15:00, C 264
Fiber enhanced Raman sensing of pharmaceutical drugs — •Torsten Frosch1, 2, Di Yan1, and Juergen Popp1, 2 — 1Leibniz Institute of Photonic Technology — 2Institute of Physical Chemistry, Friedrich Schiller University Jena
Raman spectroscopy provides excellent molecular sensitivity for the analysis of pharmaceutical drugs and can also be applied in aqueous and biological environments. However the inelastic scattering process lacks high sensitivity. This drawback can be circumvented with help of innovative micro-structured hollow core fibers [1-3]. Such hollow fibers provide a miniaturized sample container for analyte flow and act at the same time as optical waveguide. Thus a very efficient interaction of the analyte molecules and the laser was achieved and the analytical sensitivity was highly improved for tracing molecules at very low concentrations [1]. Fiber enhanced Raman spectroscopy (FERS) was for the first time extended in the important UV spectral range1 and new concepts for optical waveguides in the deep UV were developed [2].
Acknowledgment: Funding of the research project by the Free State of Thuringia (Germany) and the European Union (EFRE) is highly acknowledged (FKZ: 2012 FGR 0013).
References: [1] Frosch, T.; Yan, D.; Popp, J. Anal Chem 2013, 85, 6264-6271. [2] Hartung, A.; Kobelke, J.; Schwuchow, A.; Wondraczek, K.; Bierlich, J.; Popp, J.; Frosch, T.; Schmidt, M. A. Optics Express 2014, 22, 19131. [3] Hanf, S.; Keiner, R.; Yan, D.; Popp, J.; Frosch, T. Anal Chem 2014, 86, 5278-5285.