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DY: Fachverband Dynamik und Statistische Physik

DY 29: Statistical Physics of Biological Systems - Part II (joint session BP/DY/CPP)

DY 29.1: Talk

Wednesday, March 18, 2015, 09:30–09:45, H 1028

Pinned polymer loops in external field: how to align chromosomes for recombination? — Yen Ting Lin¹, Daniela Frömberg¹, Wenwen Huang¹, Petrina Delivani², Mariola Chacón², Iva Tolic², Frank Jülicher¹, and •Vasily Zaburdaev¹ — ¹MPI for the Physics of Complex Systems, Dresden, Germany — ²MPI of Molecular Cell Biology and Genetics

Chromatin movement and structure are central to many processes in cells such as mitosis, replication, and transcription, where physical properties of the chromatin fiber play an essential role. Motivated by the problem of chromosome alignment and recombination during meiosis we solve for the statistics of a pinned polymer ring in an external force field. We predict how the contact probability between two rings depends on the ratio of the force to the intrinsic noise level and how it changes upon addition of new recombination spots. Due to the underlying loop topology, our theoretical results are readily applicable to the description of bacterial DNA and polymer brushes.