Wuppertal 2015 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 1: Biomedical Imaging I
ST 1.1: Vortrag
Montag, 9. März 2015, 14:00–14:15, BZ.08.02 (HS 3)
Assessment of Breast Microcalcifications via X-Ray Dark-Field Radiography — •E. Braig1, K. Scherer1, L. Binbacher1, J. Schock1, K. Willer1, M. Chabior1, J. Herzen2, D. Mayr3, S. Grandl4, K. Hellerhoff4, A. Sztrokay-Gaul4, F. Bamberg4, and F. Pfeiffer1 — 1Lehrstuhl fur Biomedizinische Physik, Technische Universität München, Garching, Germany — 2Centre for Materials and Coastal Research, Helmholtz-Zentrum Geesthacht, Geesthacht, Germany — 3Department of Pathology, Ludwig Maximilian University, Munich, Germany — 4Department of Clinical Radiology, Ludwig Maximilian University, Germany
Reliable breast cancer detection in clinical mammography is strongly related to the diagnostic evaluation of breast microcalcifications [1]. In conventional mammography however, screening radiologists are restricted to the global appearance of microcalcifications within the mammogram. As a result, visual microcalcification assessment alone is often not particularly meaningful and requires further cost-intensive invasive procedures. In this study we revolutionize current microcalcification analysis by providing a clinically practicable tool for sub-resolution microcalcification assessment which utilizes the dark-field (scattering-based) contrast[2]. We were able to qualtitatively classify the mircostructure of microcalcifications as ultra-fine, fine, pleomorphic and coarse textured and verify our results by comprehensive high resolution MicroCT measurements. Our approach yields the potential to enhance cancer risk stratification with the final goal of avoiding unnecessary medical follow-up.