Hamburg 2016 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 2: Biomedical Imaging I
ST 2.2: Vortrag
Dienstag, 1. März 2016, 14:00–14:15, VMP6 HS C
Advanced signal extraction schemes for X-ray grating-based phase-contrast CT — •Mathias Marschner1, Lorenz Birnbacher1, Marian Willner1, Michael Chabior1, Julia Herzen1,2, Peter Noël1,2, and Franz Pfeiffer1,2 — 1Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, 85748 Garching Germany — 2Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, 81675 München
Grating-based phase-contrast computed tomography (gbPCCT) has gained significant attention in recent years for its ability to provide enhanced soft-tissue contrast compared to conventional, attenuation-based CT. Additionally, this technique has been shown to work with conventional laboratory X-ray sources when using three X-ray gratings. Recently, first in-vivo gbPCCT measurements of mice were successfully demonstrated. However, meaningful phase-retrieval and extraction of the dark-field signal fails in low dose scans, which are necessary for a potential clinical application of gbPCCT. We demonstrate that an advanced acquisition and processing approach that uses prior knowledge enables signal extraction even for scans with very low photon counts, where the conventional method based on Fourier analysis fails. We show superior image quality and quantitative accuracy in CT scans when using this novel approach. While it enables low-dose gbPCCT scans under certain preconditions, there are some drawbacks that need to be addressed in further research to make it more universally applicable.