Hannover 2016 – wissenschaftliches Programm

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Q: Fachverband Quantenoptik und Photonik

Q 59: Poster: Symposium Biomedical Optics (SYBO)

Q 59.2: Poster

Donnerstag, 3. März 2016, 16:30–19:00, Empore Lichthof

Separation of absorption and reduced scattering by multispectral Spatial Frequency Domain Imaging utilizing analytical solutions of the RTE — •Steffen Nothelfer, Dominik Reitzle, Florian Foschum, Philipp Krauter, André Liemert, and Alwin Kienle — Institut für Lasertechnologien in der Medizin und Meßtechnik, Helmholtzstr. 12, D-89081 Ulm, Germany

Extensive investigations on Spatial Frequency Domain Imaging (SFDI) are done for separation of absorption ( µ_a ) and reduced scattering coefficient ( µ_s′ ). However, for an accurate and absolute determination of e.g. drug concentrations, spectrally resolved measurements are generally inevitable. Moreover, structural and morphological changes of tissue or other substances mostly result in a change of the reduced scattering spectra. A new contact free and rapid method for measuring absorption and the reduced scattering coefficient spectra from 500 nm to 1000 nm is presented. Therefore a push broom spectral imager (InnoSpec, Germany) is used to map each point of a line parallel to a sinusoidal spatial intensity modulation spectrally resolved onto a CCD sensor. These images are post-processed with a special FFT algorithm to obtain the spectral resolved reflectance in the spatial frequency domain. To solve the inverse problem of separating absorption and reduced scattering, a nonlinear least squares regression is used, which applies analytical solutions of the Radiative Transfer Equation (RTE).