Regensburg 2016 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 10: Colloids and Complex Fluids III (Joint Session CPP/DY/BP)

BP 10.10: Vortrag

Montag, 7. März 2016, 17:30–17:45, H42

Self-assembled micelles as drug carriers: Influence of molar mass and chain architecture — •Bart-Jan Niebuur¹, Xiaohan Zhang¹, Natalya Vishnevetskaya¹, Petr Chytil², Sergey K. Filippov², and Christine M. Papadakis¹ — ¹Technische Universität München, Physik-Department, Garching, Germany — ²Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

A promising way to achieve site-specific delivery of anticancer agents is to use the enhanced permeation and retention (EPR) effect of self-assembled polymeric micelles. At this, a low critical micelle concentration (CMC) and particle sizes in the range of 1-100 nm are of importance.

In the present work, we focus on the importance of (i) the overall molar mass and (ii) the chain architecture. We investigate both N-(2-hydroxypropyl) methacrylamide (HPMA) [1] homopolymers with randomly distributed cholesterol side groups and diblock copolymers having a pure HPMA block and an HPMA block with cholesterol. Using fluorescence correlation spectroscopy and small-angle neutron scattering (SANS), the CMC as well as the size and structure of the micelles are determined in phosphate buffer. We find that the CMC decreases with increasing molar mass, but does not depend on chain architecture. The micellar radius is with 4-5 nm in the desired range.

[1] Filippov, S.K. et al., Biomacromolecules 13, 2594 (2012) and 14, 4061 (2013)