Regensburg 2016 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 19: Posters - Membranes and Vesicles
BP 19.8: Poster
Montag, 7. März 2016, 17:30–19:30, Poster C
Diffusion of membrane-bound ligand-receptor bonds — •Henning Stumpf1, Daniel Schmidt1,2, and Ana-Sunčana Smith1,3 — 1PULS Group, Institut für Theoretische Physik, Friedrich-Alexander Universität Erlangen-Nürnberg — 2II. Institut für Theoretische Physik, Universität Stuttgart — 3Division of Physical Chemistry, Institute Ruđer Bošković, Zagreb
Protein-mediated membrane adhesion plays a crucial role for many cell functions. In a biomimetic model system, a ligand-decorated membrane adheres to an opposing membrane representing receptors. Prior to formation of a ligand-receptor bond, both individual binders exhibit a protein-specific mobility. However, the mobility of a ligand-receptor bond is significantly decreased compared to the individual binder mobilities. Thus, a bond is often considered as immobile.
In the current work, we address the mobility of a ligand-receptor construct by analytical and numerical means. We calculate the diffusion constant of a single bond as a function of the diffusion constants of the individual binders, the elastic coupling and the affinity. Furthermore, we analyse the thermal induced displacement of the bond and find that it depends sensitively on membrane-mediated correlations between individual bonds. Moreover, entropic contributions of the unbound ligands and receptors in their respective, and possibly finite, reservoirs allow for a free energy discussion of adhesion domain formation.