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BP: Fachverband Biologische Physik
BP 29: Multicellular Systems
BP 29.9: Talk
Tuesday, March 8, 2016, 12:15–12:30, H45
Mechanosensitive regulation of cell extrusions during pupal morphogenesis of the fly wing — •Marko Popovic1, Raphael Etournay2, Franz Gruber2, Matthias Merkel1, Amitabha Nandi1, Corinna Blasse2, Gene Myers2, Guillaume Salbreux1, Suzanne Eaton2, and Frank Julicher1 — 1Max Planck Institute for Physics of Complex Systems, Dresden — 2Max Planck Institute of Molecular Biology and Genetics, Dresden
The fly wing is a double layered epithelium which significantly reshapes during pupal stages of development. Cell extrusion is a process by which cells are expelled from the epithelium. It allows the tissue to reduce the number of cells during pupal development and thus to adjust the stress in the tissue. Although extrusion rates are reproducible in wild type experiments they exhibit quantitatively different behavior in genetically and mechanically perturbed wings. How the extrusions are controlled is yet unknown. Motivated by the experimentally obsevred extrusion patters we construct a model of mechanosensitive regulation of cell extrusions. In combination with a simple continuum model, previously used to describe the fly wing development [Etournay et. al. eLife 2015], it yields a dynamical equation for extrusion rates with a single relaxation time-scale.