Regensburg 2016 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 42: Biomaterials and Biopolymers I (Joint Session CPP/MM/BP)
BP 42.1: Vortrag
Mittwoch, 9. März 2016, 15:00–15:15, H40
Self-assembled plasma protein nanofibers — •Christian Helbing1, Tanja Deckert-Gaudig2, and Klaus D. Jandt1 — 1Chair of Materials Science, Department of Materials Science and Technology, Otto Schott Institute of Materials Research (OSIM), Faculty of Physics and Astronomy, Friedrich Schiller University Jena, Jena, Germany — 2Institute for Photonic Technology, Jena, Germany
Protein nanofibers (PNFs) are promising materials for numerous applications in the field of biomedical engineering. Especially, self-assembled PNFs based on plasma proteins have a high importance due their easy fabrication and high biocompatibility. However, knowledge about the self-assembly mechanism of such PNFs is limited. The aim of the current study is to deepen the understanding of the formation mechanism. We tested the hypotheses that morphology and inner structure of PNF depends on environmental conditions. In this work, we present results of self-assembled PNF structures formed in solution from a plasma protein combination. The observed morphology of the formed PNFs depended strongly on the formation conditions. The structural analysis suggest that a partial denaturation, i.e. a change in the secondary structure, of the plasma proteins is a necessary requirement for the formation of PNFs. The comparison of the secondary structure of the PNFs and the native proteins helps to improve the understanding of the self-assembly mechanism. The current results leads to a better control during the PNF formation.