Regensburg 2016 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 64: Symposium - Anomalous Diffusion in Complex Environments (SYAD)
BP 64.5: Hauptvortrag
Donnerstag, 10. März 2016, 17:15–17:45, H15
Anomalous diffusion within cells — Sarah Klein1,2, •Cecile Appert-Rolland1, and Ludger Santen2 — 1Laboratory of Theoretical Physics, CNRS, Univ. Paris-Sud, Bat 210, 91405 Orsay, France — 2Fachrichtung Theoretische Physik, Univ. des Saarlandes D-66123 Saarbrücken, Germany
Within cells, various objects (vesicles, organelles,...) need to be transported. Some processive molecular motors get attached to these objects (or cargos) to form a complex that will have a stochastic motion along a network of microtubules. Intriguingly, there is some evidence that this motion results from a tug-of-war between teams of motors that pull in opposite directions.
A stochastic model for cargo-motors complex allows us to study the properties of the resulting motion along a single microtubule. We find some anomalous diffusion, both subdiffusive or superdiffusive depending on the timescale. Interestingly, such anomalous diffusion has indeed been observed experimentally. I will discuss the importance of fluctuations in the dynamics, and present some hypotheses why nature chose such a transport process to carry cargos through the crowded interior of cells.
[Klein, Appert-Rolland, Santen, EPL 107 (2014) 18004,
Eur. Phys. J. Special Topics 223 (2014) 3215,
EPL 111 (2015) 68005]