Regensburg 2016 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 17: Polyelectrolytes
CPP 17.3: Vortrag
Dienstag, 8. März 2016, 10:15–10:30, H40
Polyelectrolyte complex nanoparticles: Adhesive material for local delivery of drugs and proteins — •Martin Müller1,2, David Vehlow1,2, Richard Petzold1,2, Beatrice Woltmann3, Diana Wehrum3, and Ute Hempel3 — 1Leibniz-Institut für Polymerforschung Dresden e.V. — 2Technische Universität Dresden, Chemie und Lebensmittelchemie — 3Technische Universität Dresden, Physiologische Chemie
Mixing aqueous solutions of oppositely charged biorelated polyelectrolytes (PEL) in the presence of ionic compounds results in colloid dispersions of PEL complex (PEC) nanoparticles (NP) [1], which have potential for drug and protein delivery [2,3,4]. Casting these loaded PEC NP dispersions onto material surfaces results in coatings, from which drugs and proteins can be released into relevant aqueous media under local and kinetic control. Charged drugs like antibiotics and bisphosphonates and proteinogenic growth factors relevant for bone healing were loaded. Herein results on the adhesiveness and release kinetics of drug loaded PEC NP coatings under variation of drug/polycation/polyanion composition using in-situ-ATR-FTIR-, UV/VIS- and circular dichroism spectroscopy and SFM are presented [2,3,4]. Furthermore, results on the cytocompatibility of PEC NP coatings with respect to bone cells under variation of composition and net charge sign are given [4,5]. This work is sponsored by DFG (Transregio 79, Project M7). [1] Adv. Polym. Sci. 2014, 256, 197. [2] J. Pharm. Biomed. Anal. 2012, 66, 183. [3] Biointerphases 2013, 8, 25. [4] Biointerphases 2015, 10(1), 011001. [5] Int. J. Nanomedicine 2014, 9, 2205.