Regensburg 2016 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 4: Nanoparticles, Nanocrystals and Composites I
CPP 4.4: Vortrag
Montag, 7. März 2016, 10:15–10:30, H41
Tailoring the Physicochemical Properties of Protein-Coated Gold Nanoparticles — •Jonas Schubert1, Inna Dewald2, Olga Isakin2, Tobias Kraus3, and Munish Chanana4 — 1Leibniz Institute of Polymer Research Dresden, 01069 Dresden, Germany — 2Physical Chemistry II, University of Bayreuth, 95447 Bayreuth, Germany — 3INM Leibniz-Institut for New Materials, 66123 Saarbrücken, Germany — 4Institute of Building Materials (IfB), ETH Zurich, 8093 Zurich, Switzerland
The investigation of the behavior of nanoparticles in the environment begins with the detection of their physicochemical properties. It has up to now not been successful to connect their properties with their behavior because of the undefined adsorption of proteins onto the surface of the nanoparticles, which changes their properties drastically. One approach to circumvent this is to generate a defined protein corona. In this work, we present gold nanoparticles successfully coated with a variety of proteins, which differ in their physicochemical properties (MW, pI). These properties and the environmental conditions (pH, ionic strength) determine the colloidal stability of the nanoparticles during and after the protein adsorption in a certain pH range. Eventually, the physicochemical properties of the successfully coated NPs can be tailored by the choice of protein, the coating pH and the purification pH.
Dewald, I.; Isakin, O.; Schubert, J.; Kraus, T.; Chanana, M., J. Phys. Chem. C, 2015, 119, 25482-25492.