Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 19: Posters - Computational Biophysics
BP 19.1: Poster
Dienstag, 21. März 2017, 14:00–16:00, P1A
Morphological properties of the epithelial tissue — •Jakov Lovrić1,2, Sara Kaliman2, and Ana-Sunčana Smith1,2 — 1Institute Ruđer Bošković, Division of Physical Chemistry, Group for Computational Biosciencies, Zagreb, Croatia — 2Institute for Theoretical Physics, PULS Group and Cluster of Excellence: EAM, FAU Erlangen-Nürnberg, Germany
Knowing the morphology of an epithelial tissue is important due to understanding proceses like growth and development of the tissue, wound healing and progression of the cancer.
We study the structure of the MDCK II epithelial cells in circular colonies. Cell nuclei can be approximated with ellipses and the Voronoi tesselation generated by those ellipses coincides well with the cell membranes. We compare the tissue cells to the Voronoi cells generated by randomly packed ellipses obtained from the cell nuclei. The comparison is done by studying the probability distributions of chosen morphological measures calculated from the cells. We find that randomly packed ellipses reproduce the morphology of the tissue well at the low cell density. At high cell density we observe more regular structure of the tissue an we see the deviations of the random model from the cell tissue.