Dresden 2017 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 21: Posters - Membranes and Vesicles

BP 21.14: Poster

Dienstag, 21. März 2017, 14:00–16:00, P1A

Functional reconstitution of ion channels in lipid bilayers in a microfluidic device — •Philipp Hannibal1, Thomas Baukrowitz2, Stefan Klumpp3, and Christoph F. Schmidt11III. Physikalisches Institut, Universität Göttingen, Germany — 2Physiologisches Institut, Christian-Albrechts-Universität zu Kiel, Germany — 3Institut für Nichtlineare Dynamik, Universität Göttingen, Germany

Membrane channel proteins play crucial roles for signaling and sensory processes across the cell membrane. We work with potassium-selective K2P channels that are sensitive to temperature, voltage, pH, drugs or mechanical forces. Several of these K2P channel proteins show diode-like current-voltage-dependencies when they are embedded in lipid bilayers [1].

The goal of this work is to create a microfluidic device with reconstituted lipid bilayers and inserted functional channels with electrical access so that channel currents can be measured in simple and complex geometries.

[1] Schewe, M. et al., A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels, Cell, 2016, Vol. 164-5, pp. 937-949.

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