Dresden 2017 – wissenschaftliches Programm
Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
BP: Fachverband Biologische Physik
BP 21: Posters - Membranes and Vesicles
BP 21.14: Poster
Dienstag, 21. März 2017, 14:00–16:00, P1A
Functional reconstitution of ion channels in lipid bilayers in a microfluidic device — •Philipp Hannibal1, Thomas Baukrowitz2, Stefan Klumpp3, and Christoph F. Schmidt1 — 1III. Physikalisches Institut, Universität Göttingen, Germany — 2Physiologisches Institut, Christian-Albrechts-Universität zu Kiel, Germany — 3Institut für Nichtlineare Dynamik, Universität Göttingen, Germany
Membrane channel proteins play crucial roles for signaling and sensory processes across the cell membrane. We work with potassium-selective K2P channels that are sensitive to temperature, voltage, pH, drugs or mechanical forces. Several of these K2P channel proteins show diode-like current-voltage-dependencies when they are embedded in lipid bilayers [1].
The goal of this work is to create a microfluidic device with reconstituted lipid bilayers and inserted functional channels with electrical access so that channel currents can be measured in simple and complex geometries.
[1] Schewe, M. et al., A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels, Cell, 2016, Vol. 164-5, pp. 937-949.