Dresden 2017 – wissenschaftliches Programm
BP 21.6: Poster
Dienstag, 21. März 2017, 14:00–16:00, P1A
Diffusion of membrane-bound ligand-receptor bonds — •Henning Stumpf1, Daniel Schmidt1, and Ana-Sunčana Smith1,2 — 1PULS Group, Institut für Theoretische Physik I, Friedrich-Alexander-Universität Erlangen-Nürnberg — 2Division of Physical Chemistry, Institute Ruđer Bošković, Zagreb
Protein-mediated membrane adhesion plays a crucial role in a number of biological processes including the immune response and morphogenesis. We aim to understand the effect of lateral interactions between two adhesion bonds on the mobility of the bonds. In the current work, we address this problem by numerical and simulation means. In principle, we find that two adhesive bonds strongly attract each other at short distances and repel at large distances. Naturally such an interaction has a barrier at intermediate separations. We calculate the time it takes for one bond to escape from the attractive well. We also determine the effective diffusion constant of a bond diffusing through an adhesion domain represented by a periodic arrangement of affixed ligand-receptor constructs. This is an important step in understanding the diffusion of bonds, which have recently been measured, and consequently understand the role of the membrane in the process of cell adhesion.