Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 22: Posters - Biomaterials and Biopolymers
BP 22.1: Poster
Dienstag, 21. März 2017, 14:00–16:00, P1A
Humidity-controlled gelatin bioactuator — •Stefanie Riedel1, Benedikt Heyart1, Katharina Apel1, and Stefan G. Mayr1,2 — 1Leibniz-Institut für Oberflächenmodifizierung e. V., Leipzig, Germany — 2Fakultät für Physik und Geowissenschaften, Universität Leipzig, Leipzig, Germany
Natural hydrogels such as gelatin are of particular interest in biology and medicine. Due to their strong biocompatibility and biodegradability, they are highly attractive materials in regenerative medicine as extracellular matrix component. Furthermore, stimuli responsiveness of hydrogels attracts considerable interest due to the potential use in sensor and actuator applications. In regard to these applications, adaption of stimuli-responsiveness is an interesting aspect of gelatin modification. Modification of hydrogels can be achieved by crosslinking for which several methods exist. An important method is high energy irradiation by using highly energetic electrons. In contrast to several other crosslinking methods, electron irradiated gelatin is nontoxic and thus beneficial for biological applications. In the presented poster, we show a stimuli-responsive system made up from electron irradiated gelatin that becomes actuated upon exposure to humidity. Furthermore, we demonstrate how adjustment of system's and environmental properties such as gel concentration, irradiation dose, pH and salt concentration allows fine-tuning of the system's response.