Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 22: Posters - Biomaterials and Biopolymers
BP 22.4: Poster
Dienstag, 21. März 2017, 14:00–16:00, P1A
Magnetic nanoparticles-filled carbon nanotubes as potential thermo-seed for Hyperthermia — •Rasha Ghunaim1, Sebastian Schulz2, Christian Kobrow2, Silke Hampel1, Ruediger Klingeler2, and Bernd Buechner1,3 — 1IFW-Dresden, Germany — 2Kirchhoff Institute for Physics,Heidelbeg,Germany — 3TUD-Dresden,Germany
Hyperthermia can be considered as a promising tool for cancer treatment; based on the prolonged and controlled exposure of the body tissues to a temperature in the range of 40-43 °C.Magnetic nanoparticles (MNPs) are considered as promising tools for an effective therapeutic approach against cancer. These MNPs can be heated up in a (AC) magnetic field, which leads to their use as hyperthermia candidates, this magnetic-based hyperthermia is called magnetic fluid hyperthermia (MFH). However, to consider these MNPs safe and effective for the patient, they are encapsulated inside the hollow cavity of carbon nanotubes (CNTs). These nano-carries are chemically stable (protect MNPs from oxidation due to interaction with the biological system), biocompatible (can easily penetrate biological barriers) and have functionalizable surface (for better bonding with matrix elements and compounds.In this work, the current candidates for MFH are mainly binary alloys of Fe-Co, Fe-Ni, Ni-Cr, Ni-Cu and Co/Ni-ferrites.Their feasibility for magnetic hyperthermia therapies is exploited by investigating induced heating under AC magnetic field. Quantitatively, their Specific Absorption Rate (SAR) can give a hint about the amount of heat released by unit mass of material per unit time