Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 25: Posters - Cytoskeletal Filaments
BP 25.12: Poster
Dienstag, 21. März 2017, 14:00–16:00, P2-EG
Transition from a linear to a harmonic potential in collective dynamics of a multifilament actin bundle — •Jörg Schnauß1,2, Tom Golde1, Carsten Schuldt1,2, B.U. Sebastian Schmidt1, Martin Glaser1,2, Dan Strehle1, Tina Händler1,2, Claus Heussinger3, and Josef A. Käs1 — 1Institute for Experimental Physics I, Leipzig University, Germany — 2Fraunhofer IZI, Leipzig, Germany — 3Institute for Theoretical Physics, Georg-August University of Göttingen, Germany
Modeling approaches and recent experimental data have shown that depletion forces between suspended, rod-like particles display different signatures depending on the orientation of these particles. It has been shown that depletion-driven, axial attraction of two rods yields a constant contractile force of 0.1 pN, which corresponds to a linear energy potential. We extended these pairwise interactions to a multi-filament level by investigating arising dynamics within actin bundles. Without any additional proteins such as crosslinkers or molecular motors, we found contractile forces in a biologically relevant regime of up to 3 pN. Generated forces due to bundle relaxation were not constant as in a two filament case, but decayed exponentially with a mean decay time of 3.4 s. These different dynamics are explained within the frame of a mathematical model (and supported by simulations) by taking pairwise interactions to a multi-filament scale [1].
[1] Schnauß et al.: Transition from a Linear to a Harmonic Potential in Collective Dynamics of a Multifilament Actin Bundle, Phys. Rev. Lett. 116, 108102 (2016)